The correlation of HLA-DR gene and sarcoidosis in Chinese population

摘要：

Objective　To investigate the correlation of HLA-DR gene with susceptibility and clinical manifestations of sarcoidosis. Method　Fifty-five patients with sarcoidosis and 106 normal subjects were investigated by using allele group specific polymerase chain reaction technique （PCR）. Results　The gene frequency of HLA-DR5 increased significantly in patients with sarcoidosis （P＜0.01）, but that of HLS-DR7 decreased （P＜0.05）. Gene frequencies of HLA-DR9 and HLA-DR5 increased remarkably in male patients and in patients with stage Ⅰ and stage Ⅱ a, respectively （P＜0.05）. Conclusion　HLA-DR gene might contribute to the susceptibility and differently clinical manifestations of sarcoidosis.

关键词：HLA-DR gene、Sarcoidosis、Polymerase chain reaction

所属期刊栏目：37

在线出版日期：2021-04-06（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：33-35