国家自然科学基金82103920,82192904,82192901,82192900,81941018;国家重点研发计划2020YFC2003405;国家重点研发计划“精准医学研究”重点专项2016YFC0900500;中国香港Kadoorie Charitable基金82103920, 82192904, 82192901, 82192900, 81941018;National Natural Science Foundation of China2020YFC2003405;National Key Research and Development Program of China2016YFC0900500;"Precision Medicine Research" Key Project, National Key Research and Development Program of China;Kadoorie Charitable Foundation in Hong Kong of China