国家自然科学基金82192900,82192901,82192904;国家重点研发计划“精准医学研究”重点专项2016YFC0900500,2016YFC0900501;中国香港Kadoorie Charitable基金212946/Z/18/Z,202922/Z/16/Z,104085/Z/14/Z,088158/Z/09/Z;英国Wellcome Trust82192900, 82192901, 82192904;National Natural Science Foundation of China2016YFC0900500, 2016YFC0900501;"Precise Medicine Research" Key Project, National Key Research and Development Program of China212946/Z/18/Z, 202922/Z/16/Z, 104085/Z/14/Z, 088158/Z/09/Z;Kadoorie Charitable Foundation in Hong Kong of China;Wellcome Trust in the UK