国家自然科学基金82173589,82173590,81941021;首都卫生发展科研专项2022-2G-5031;国家重点研发计划2018YFC2000400;National Natural Science Foundation of China82173589, 82173590, 81941021;Capital's Funds for Health Improvement and Research2022-2G-5031;National Key Research and Development Program of China2018YFC2000400