公益性行业科研专项201502006;国家自然科学基金81072373;苏州市科教兴卫项目Szxk201816,KJXW2018051;Special Fund for Health Scientific Research in Public Welfare201502006;National Natural Science Foundation of China81072373;Suzhou Science and Technology Bureau Fund for Technology for PeopleSzxk201816, KJXW2018051