国家重点研发计划2017YFE0103800;国家科技重大专项2018ZX10721102- 003-004;山东省医药卫生科技发展计划2019WS430;National Key Research and Development Program of China2017YFE0103800;National Science and Technology Major Project of China2018ZX10721102-003-004;Shandong Provincial Medical and Health Science and Technology Development Program2019WS430