中国医学科学院医学与健康科技创新工程2019-I2M-2-004;国家自然科学基金81974492;深圳医疗卫生三名工程SZSM201911015;Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences2019-I2M-2-004;National Natural Science Foundation of China81974492;Sanming Project of Medicine in ShenzhenSZSM201911015