国家重点研发计划2018YFC1311205, 2018YFC1312401, 2018YFC1312404;中国医学科学院医学与健康科技创新工程2016-I2M-1-006;国家卫生健康委员会重大公共卫生服务项目2018ZX09201012;国家科技重大专项2018YFC1311205, 2018YFC1312401, 2018YFC1312404;National Key Research and Development Program of China2016-I2M-1-006;Chinese Academy of Medical Sciences Innovation Fund for Medical Science2018ZX09201012;Major Public Health Service Project from the Ministry of Finance and National Health Commission of China;National Science and Technology Major Project of China