国家重点研发计划2016YFC0905400,2017YFC0907900,2016YFC1302500;国家自然科学基金81673265;中国医学科学院医学与健康科技创新工程2017-I2M-B;北京协和医学院“协和青年基金”3332016131,2017320013National Key Projects of Research and Development of China2016YFC0905400,2017YFC0907900,2016YFC 1302500;National Natural Science Fund of China81673265;Chinese Academy of Medical Sciences Initiative for Innovative Medicine2017-I2M-B;Peking Union Medical College Youth Fund3332016131,2017320013