浙江省重大科技专项2013C03047-1;2015年浙江省医药卫生一般研究计划2015KYB082;2016年浙江省医药卫生一般研究计划2016KYA066Major Special Project of Science and Technology of Zhejiang Province2013C03047-1;General Program of Health and Family Planning Commission of Zhejiang Province, 20152015KYB082;General Program of Health and Family Planning Commission of Zhejiang Province, 20162016KYA066