National Science and Technology Major Project of China2012ZX10001006;Key Laboratory Project of Department of Education of Liaoning ProvinceLZ2014038;Science Fund Project of the First Affiliated Hospital of China Medical University FSFH1512国家科技重大专项2012ZX10001006;辽宁省教育厅重点实验室项目LZ2014038;中国医科大学附属第一医院科技基金FSFH1512