浙江省自然基金LQY18H260001、LGD21C040008;浙江省医药卫生面上项目2018KY343、2019KY360、2020KY528、2021KY128;浙江省教育厅面上项目Y202045373;Natural Science Foundation of Zhejiang ProvinceLQY18H260001, LGD21C040008;Medical Health Science and Technology Project of Zhejiang Provincial Health Commission2018KY343, 2019KY360, 2020KY528, 2021KY128;Education Department Project of Zhejiang ProvinceY202045373