广东省自然科学基金2020A151501893;广东省职业病防治重点实验室2017B0303 14152;广东省医学科研基金A2015626、A2014072;Natural Science Foundation of Guangdong Province2020A151501893;Guangdong Province Key Laboratory of Occupational Disease Prevention and Treatment2017B030314152;Guangdong Medical Research FundA2015626, A2014072