江苏省青年医学人才项目QNRC2016536;江苏省卫生健康委科研课题Y2018076;江苏省"333工程"科研项目BRA2018398 Fund program:Jiangsu Provincial Young Medical Talent ProjectQNRC2016536;Scientific Research Project of Jiangsu Health CommissionY2018076;Scientific Research Project of "333 Project" in Jiangsu ProvinceBRA2018398