国家自然科学基金81201064,81571344;江苏省自然科学基金BK20161109;江苏省科技计划重点病种项目BE2015609 National Natural Science Foundation of China81201064,81571344;Natural Science Foundation of Jiangsu Province of ChinaBK20161109;Science and Technology Planning Project of Jiangsu Province of ChinaBE2015609