国家自然科学基金81571639,81371522,61372032;国家高技术研究发展计划863计划2015AA020509;江苏省临床医学科技专项BL2014009National Natural Science Foundation of China81571639,81371522,61372032;National High-tech Research and Development Program of China 863 program2015AA020509;Clinical Medicine Technology Foundation of Jiangsu ProvinceBL2014009