Major depressive disorder and the gut microbiome:what is the link?
INTRODUCTION
Major depressive disorder(MDD)manifests by persistent depressed mood,anhedonia,changes in sleep and appetite,fatigue,guilt as well as hopelessness and suicidality.1 MDD is quite prev-alent and remains a leading cause of disease burden worldwide.2 Antidepressants in combi-nation with psychotherapies are helpful but do not work for all persons with MDD.In fact,30%-50%of depressed patients exhibit only a partial response to antidepressants with signif-icant residual symptoms.3 Conversely,about 10%-30%of patients with MDD are resistant to the therapeutic effects of antidepressants and are classified as treatment non-responders.3 This variability in treatment response among these patients may reflect diverse pathogenesis of yet undetermined subgroups of MDD.4 Biological markers have implicated multiple mechanisms including neuroinflammation,neuroendocrine changes and gut microbiome abnormalities.2 4 While there is no clear pathway unifying these theories,the mapping of the human microbiota offers new avenues of exploration.
what、link、depressive、disorder、major、microbiome
36
H314;D6;TP391.8
2023-04-26(万方平台首次上网日期,不代表论文的发表时间)
共3页
67-69