国家自然科学基金72204225,72274179;中国博士后科学基金2023M733234;河南省医学科技攻关项目SBGJ202102076,222102310246,LHGJ20220429;National Natural Science Foundation of China72204225, 72274179;China Postdoctoral Science Foundation2023M733234;Medical Science and Technology Project of Henan ProvinceSBGJ202102076, 222102310246, LHGJ20220429