国家重点研发计划2016YFE0128400;2016YFC0905100;中国医学科学院医学与健康科技创新工程项目2016-12M-3-003;国家自然科学基金81871749;National Key Research and Development Program of China2016YFE0128400; 2016YFC0905100;CAMS Innovation Fund for Medical Sciences2016-I2M-3-003;National Natural Science Foundation of China81871749