国家自然科学基金资助项目81471797,81572217;浙江省医药卫生科技项目201340612、2015112091;宁波市创新团队项目2015B11050National Nature Foundation of China81471797、81572217;Zhejiang Province medical and health science and technology projects201340612、2015112091;Ningbo innovative team projects2015B11050