国家自然科学基金81272046,31670983,31470937,31500781;天津市自然科学基金15JCYBJC25300;天津市卫计委攻关课题14KG121,15KG125National Natural Science Foundation of China81272046,31670983,31470937,31500781;Natural Science Foundation of Tianjin15JCYBJC25300;Key Research Foundation of the Tianjin Health Bureau14KG121,15KG125