National Natural Science Foundation of China for the Youth81601460;Miaozi Project of Science and Technology Innovation Program of Sichuan Province16-YCG061;Scientific Research Fund of Health and Family Planning Commission of Sichuan Province 16PJ245,16PJ243国家自然科学基金青年基金资助项目81601460;四川省科技创新苗子工程培育项目16-YCG061;四川省卫生计生委科研课题16PJ245、16PJ243