国家自然科学基金项目81302273;湖北省卫生计生委面上项目WJ2015MB084;湖北省科技厅科技支撑计划项目2015BCA313National Natural Science Foundation of China81302273;General Program of Health and Family Planning Commission of Hubei ProvinceWJ2015MB084;Science and Technology Infrastructure Program of Science and Technology Department of Hubei Province2015BCA313