重庆市自然科学基金CSTB2022NSCQ-MSX1220;重庆市科卫联合医学科研项目2022QNXM030,2022ZDXM034;中国医学科学院医学与健康科技创新工程2021-12M-1-042;Natural Science Foundation of ChongqingCSTB2022NSCQ-MSX1220;Chongqing Science and Technology Bureau and Health Commission Joint Medical Project2022QNXM030, 2022ZDXM034;CAMS Innovation Fund for Medical Sciences2021-12M-1-042