Mitochondria as extranuclear targets of ionizing radiation

摘要：

According to classical theory of radiation biology,the main target of ionizing radiation damage is believed to be the DNA in the cell nucleus.However,the discovery of so-called non-target effects,such as radiation-induced genomic instability in the progeny of cells survived from irradiation and bystander effects on cells not directly exposed to radiation,has challenged the central dogma of radiation biology in recent years”1-3”.Previous studies have demonstrated that extranuclear target also plays an important role in mediating the genotoxicity of ionizing radiation”4”,but the details of the cytoplasmic effects on genomic instability in hit cells is largely unexploited,mainly due to the technical difficulties in selectively targeting the cytoplasm without affecting the nucleus.

所属期刊栏目：35

在线出版日期：2015-03-11（万方平台首次上网日期，不代表论文的发表时间）

页数：共5页

页码：3-7