北京市科委“首都临床特色应用研究”专项课题Z18110000171837;中国博士后科学基金面上资助项目2019M650773;科技部“十三五”国家重点研发计划2016YFC1301500;河北省卫计委医学科学研究重点科技研究计划20181258;Beijing Municipal Science and Technology CommissionZ18110000171837;China Postdoctoral Science Foundation2019M650773;National Key Research and Development Program of China2016YFC1301500;Hebei Provincial Health and Family Planning Commission20181258