国家自然科学基金81571412;北京市医院管理局临床医学发展专项"扬帆"计划ZYLX201406;首都医科大学基础-临床科研合作基金16JL44 National Natural Science Foundation of China81571412;Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special FundingZYLX201406;Collaboration Fund for Basic-Clinical Scientific Reserch of Capital Medical University16JL44