国家自然科学基金资助项目81460097;广西医疗卫生适宜技术研究与开发课题S20142105;广西壮族自治区卫生厅自筹经费科研课题No:Z2014215、Z2015351、Z2016593及Z2016608 Fund project:the national natural science fund project81460097;Guangxi healthcare suitable technology research and devel-opment projectS201421_05;The guangxi zhuang autonomous region health department self-financing scientific research subjectZ2014215 Z2015351 Z2016593 and Z2016608