国家自然科学基金面上项目81570516、81270936;“十二五”国家科技支撑计划项目2012BAI09B04;上海市教委高峰计划20152520National Natural Science Foundation of China81570516,81270936;The National Key Technology R&D Program2012BAI09B04;Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support20152520