福建省自然科学基金2016J01508,2018J01264;福建省创新课题2017-CXB-2;福建省卫计委中青年骨干人才培养项目2016-ZQN-17Natural Science Foundation of Fujian Province2016J01508, 2018J01264;Medical Innovation Program of Fujian Province2017-CXB-2;Training Project for Young and Middle-Aged Core Talents of Health System in Fujian Province2016-ZQN-17