国家自然科学基金资助项目30571844;山东省自然科学基金资助项目ZR2013HM089;吴阶平医学基金资助项目No.320.6750.12393. Project supported by the National Natural Science Foundation of China30571844;the Natural Science Foundation of Shandong ProvinceZR2013HM089;the Wu Jie Ping Medical Foundation320.6750.12393