国家自然科学基金资助项目No.81270634,81470278;天津市应用基础与前沿技术研究计划项目青年项目No.15JCQNJC10300;协和青年科研基金滚动自助项目No.33320140066.Project supported by the National Natural Science Foundation of China No.81270634,81470278,the Youth Program of Applied Basic Research Foundation of TianjinNo.15JCQNJC10300,and the Science-Technology Foundation for Young Scientists of Chinese Academy of Medical Sciences&Peking Union Medical CollegeNo.33320140066