本文课题受国家自然科学基金81402420;天津市自然科学基金15JCQNJC12400;天津市卫生局科学基金16KG25;天津市教委科学基金编号:2017KJ202资助 This work was supported by the National Natural Science Foundation of China81402420;Tianjin Natural Science Foundation15JCQNJC12400;Tianjin Municipal Health Bureau Grant16KG125;Tianjin Education Commission Science Foundation2017KJ202