课题受国家自然科学基金项目81572372;国家重点研发计划"重大慢性非传染性疾病防控研究"项目2016YFC1303202;国家重点研发计划"精准医学研究"项目编号:2017YFC0908300资助 This work was supported by the National Natural Science Foundation of China81572372;National Key Research and Develop-ment Program "the Major Chronic Non-infectious Disease Prevention and Control Research"2016YFC1303202;National Key Re-search and Development Program "Precision Medicine Research"2017YFC0908300