国家自然科学基金面上项目81473627;上海市自然科学基金面上项目14ZR1439000;上海市市级医院新兴前沿技术联合攻关项目No.SHDC12014127.General Program of National Natural Science Foundation of China81473627;General Program of Natural Science Foundation of Shanghai14ZR1439000;Shanghai Municipal Hospital Emerging Frontier Technology Joint Research ProjectSHDC12014127