国家重点基础研究发展计划973计划No.2013CB531801,国家自然科学基金项目No.8150141683,黑龙江中医药大学校科研基金No.201504 National Key Basic Research Program of China 973 Program No.2013CB531801,National Natural Science Foundation of China No.8150141683,Scientific Research Foundation of Heilongjiang University of Chinese Medicine No.201504