国家自然科学基金81471681;北京市自然科学基金15G30083;中国人民解放军总医院临床科研扶持基金项目2015PC-TSYS-2022Supported by the National Natural Sciences Foundation of China81471681;the Beijing National Science Foundation15G30083;the Clinical Research Support Foundation of PLA General Hospital2015PC-TSYS-2022