国家自然科学基金81541131;国家国际科技合作专项项目2015DFA30440;首都卫生发展科研专项基金2016-2-40110 Supported by the National Natural Sciences Foundation of China81541131;the International Science and Technology Cooperation Program of China2015DFA30440;the Special Fund for Research on Health Development of the Capital2016-2-40110