国家“重大新药创制”科技重大专项资助项目2012ZX09304-001;中央高校基本科研业务费专项资金资助项目PY2014ZY0008;This study was supported by China National Key High-Tech Innovation Project for the R&D of Novel Drugs2012ZX09304-001;the Fundamental Research Funds for the Central UniversitiesPY2014ZY0008