National Natural Science Foundation of China 81360295;National Key Clinical Specialities Construcion Program of China;Scientific and Technological Foundation of Guizhou Province ”LKZ201230”;Scientific and Technological Foundation of Youth Talents of Guizhou Province ”2013No.12”;国家自然科学基金资助项目81360295;国家临床重点专科建设项目;贵州省科学技术基金资助项目黔科合J字LKZ”2012”30号;贵州省优秀青年科技人才培养对象专项资金资助项目”黔科合人字201312号”