福建省自然科学基金2015J01422;福建省医疗创新基金2017?CX?2;福建省卫生计生委青年科研课题2018?2?5;福建医科大学启航基金2017XQ1151 Fund program:Natural and Science Foundation of Fujian Province,China2015J01422;Foundation for Medical Innovation of Fujian Province2017?CX?2;Youth scientific research project of Fujian Provincial Health and Family Planning Commission2018?2?5;Sail Fund of Fujian Medical University2017XQ1151