国家自然科学基金30960445、81560472;云南省科技厅-昆明医科大学联合专项2013FB172;云南省卫生厅内设机构研究项目2014NS017;云南省肿瘤医院博士科研基金BSJJ201405、BSJJ201410 This work was supported by Grants from the National Natural Science Foundation of China30960445,81560472;Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University2013FB172;Funds for Equipped Research Institutions of Yunnan Provincial Health Department2014NS017;PhD research fund of Tumor Hospital of Yunnan ProvinceBSJJ201405,BSJJ201410