Human symbiont Bacteroides xylanisolvens attenuates NASH through intestinal nicotine catabolism
Tobacco use increases the risk of many diseases,such as lung cancer,chronic obstructive pulmonary disease,and coronary heart disease.Smoking is the most preventable cause of death,responsible for over 6 million deaths world-wide each year.The average life expectancy of smokers is re-duced by 10 years compared to those who never smoke[1].Nicotine accumulates in the upper gastrointestinal tract dur-ing smoking,which may lead to pathological damage.Smoking is positively associated with the development of non-alcoholic fatty liver disease(NAFLD).However,the underly-ing molecular mechanism for the correlation of nicotine with NAFLD is still unknown.Reporting in Nature,CHEN and co-workers found that nicotine accumulated in the intestine dur-ing smoking accelerated the occurrence of NAFLD.Moreover,this study demonstrated that the human gut bac-terium Bacteroides xylanisolvens(B.xylanisolvens)effect-ively degrades ileal nicotine[2].
bacteroides、nicotine、through、human、nash、attenuates、catabolism、intestinal、symbiont、xylanisolvens
21
R965(药理学)
2023-03-24（万方平台首次上网日期，不代表论文的发表时间）
共2页
81-82
