Fast-onset antidepressant targeting the nNOS-SERT interaction in the DRN
Major depressive disorder is one of the most deleterious mental disorders with a high suicide rate,incidence and re-currence rate,which is manifested as continuous depression,retardation of thinking as well as loss of appetite and sleep disturbances[1,2]In addition,depression is a principal cause of disability and physical labor loss worldwide[3,4].Based on the hypothesis of predominant monoaminergic neurotransmit-ter deficiency towards depressive disorders,a series of anti-depressants have been developed to inhibit the re-uptake of monoamine,especially serotonin(5-hydroxytryptamine)and noradrenaline.However,the drugs based on the monoamine deficiency hypothesis exert slow-onset effects,and patients with depression are usually reluctant to take currently avail-able antidepressant drugs[5].In China,traditional Chinese medicines have been long used to treat brain diseases[6-9].Several traditional Chinese medicines have displayed good therapeutic effects on depression,such as Sini Powder,Lily Bulb and Rehmannia Decoction,and so on[2,10,11]but they also exert limited therapeutic effects on depression due to un-pleasant side effects.Thus,there is an urgent need for new therapeutic strategies to develop fast-onset antidepressants against major depressive disorder.
interaction、antidepressant、fast-onset、nnos-sert、targeting
21
R965(药理学)
2023-02-27（万方平台首次上网日期，不代表论文的发表时间）
共2页
1-2
