the Natural Science Foundation of China31101241;the Natural Science Foundation of Shandong Province,ChinaQ2007C13;the Shandong Administration of Traditional Chinese Medicine2009-152;the Independent Innovation Foundation of Shandong University IIFSDU,No.2012TS163.国家自然科学基金31101241;山东省自然科学基金Q2007C13;山东省中医药科学技术研究项目2009-152;山东大学自主创新基金2012TS163