国家重大科学研究计划2012CB955503;国家科技重大专项2012ZX10004219-002;卫生行业科研专项201202006Supported by the National Basic Research Program of China 973 Program2012CB955503;National Science and Technology Major Project of China2012ZX10004219-002;the Special Fund for Health Sector,People's Republic of China201202006