国家科技重大专项2012ZX10004220;浙江省公共卫生重点学科群建设项目XKQ-009-003;嘉兴市重点科技项目2013AY21036Supported by the National Science and Technology Major Project of China No.2012ZX10004220,the Major Discipline Construction Project of Public Health of Zhejiang Province No.XKQ-009-003 and the Major Technology Project of Jiaxing City No.2013AY21036