PROTECTIVE EFFECT OF GREEN TEA FROM PAF-INDUCED NEUROTOXITY
Objective The protective effect of chinese green tea from PAF-induced neurotoxity was investigated Method LaN1 ( neuroblastoma cell line) was used as neuron. Lactate dehydrogenase (LDH) -release was an indicator of cell death. Cytoplasmic calcium was measured with Aequouin-loaded method. Results When applied to LaN1 cells, green tea in concentration 2mg/ml or stronger obviously damaged cells. If lower concentration (0. 5mg/ml and l.Omg/ml) of green tea were applied, green tea inhibited the elevation of intracellular calcium and reduced the cytotoxity induced by PAF in neurons. Conclusion PAF plays an important role in brain injury and stroke, the protective effect of green tea could be a basis to explore weather green tea or its derivative may have preventive and therapeutic potential for neuronal injury.
green tea、protective effect、therapeutic potential、intracellular calcium、neuronal injury、brain injury、cell line
8
R3 ;R73
2005-07-07（万方平台首次上网日期，不代表论文的发表时间）
共1页
98
