Experimental research on functional imaging of Parkinson”s disease
Objective To analyse the change of density of dopamine transporter (DAT) in striatum of hemiparkinsonian monkeys by SPECT inaging with 99mTc-TRODAT i. Methods four rhesus monkeys were used for this study, and named M1-4. M1 was normal monkey, others were hemiparkinsonian models induced by unilateral infusion of MPTP into the right common carotid artery. Acquisitions were performed 1~2 hours after an injection ot 370 ~550MBq 99mTc-TRODAT-1, exceilent imagings were selected for analysis. Regions of interest(ROls)were drawn over the striata and the cerebral cortexes. Results In healthy monkey (M1), Left striatum/right striatum ratio was 1.00 in the radioactivtity of RO1, but in hemiparkinsonian monkeys, left striatum/right striatum ratios were 1.10~1.22, and right striatum/cerebral cotexes ratios were decreased compared with that of left striatum/corebral cotexes. Conclusion SPECT imaging with 99mTc-TRODAT-1 can be used to in vivoo evaluate the loss of DAT in the striatum of the hemiparkinsonian monkeys, and to adjunctively make a diagnosis for Parkinson”s disease, even in the earlier stage.
common carotid artery
8
R73
2005-07-07(万方平台首次上网日期,不代表论文的发表时间)
共1页
90