Hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia in rabbits
Objective To determine whether the ischemic tolerance could be induced in the spinal cord by pretreated with Hyperbaric oxygen (HBO). Methods 23 New Zealand white rabbits(2. 1 ±0.3Kg) were randomly assigned to three groups. Control Group: n=8,no hyperbaric oxygen was applied before spinal cord ischemia; HBO-1 Group: n=8,hyperbaric oxygen (2.5ATA, 100% O2, 1 hr per day) pretreated for 3 days before ischemia; HBO-2 Group: n=7, hyperbaric oxygen pretreated for 5 days before ischemia. Infrarenal aorta clamping modal was used in this study. Ischemia lasted for 20-min. MAP(proximal Distal)- HR、 PaO2、 PaCO2、 pH、 rectal temperature and plasma glucose were measured during experiment. Results The neurologic outcome both in HBO-1 and HE-2 Groups were better than that of Control Group (P＜0.05). The neruologic outcome in HBO-2 was better than that of HBO-1 Group (P＜0.05). The normal neurons in the anterior spinal cord of HBO-2 Group were more than that of Control and HBO-1 Groups.The number of normal neurons in the anterior spinal cord of HBO-1 Group was similar with that of Control Group. Conclusion hyperbaric oxygen preconditioning could induce ischemic tolerance on spinal cord in rabbits. 5 days period of HBO preconditioning induce stronger ischemic tolerance than 3 days of HBO preconditioning.
Hyperbaric oxygen、spinal cord ischemia、used in
8
R65;R74
2005-07-07（万方平台首次上网日期，不代表论文的发表时间）
共1页
77
